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Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes

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For example, MRI scans were recently reinstated into a Phase 1 protocol due to the value of obtaining preliminary body composition data that could guide endpoint assessments for later pivotal trials

In addition to being expressed in venom, exendin-4 is also produced endogenously in the Gila monster, where it slows down digestion and helps maintain blood glucose despite long periods of fasting

Glutathione is metabolised via the gamma-glutamyl cycle, which is catalyzed by six enzymes

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